Metabolic syndrome begins when insulin clearance is less efficient

Metabolic syndrome begins when insulin clearance is less efficient

January 15, 2020 5 By Jose Scott


When it comes to metabolic troubles, the focus
is always on INSULIN PRODUCTION. We’re trying to get cells to RESPOND to the insulin, specifically,
we want them to open the glucose gates, so that sugar molecules can be cleared from the
blood. But, THEY RESIST………….we call it insulin resistance and it is the biochemical
problem, that underpins metabolic syndrome. People with insulin resistance are NOT short
of insulin, they’re swimming in the stuff. And, too much insulin, is responsible for
many of the health problems, associated with metabolic syndrome. So why are they swimming
in insulin ? Well, maybe it’s a plumbing problem….. Join us for this episode of BETTER
BODY CHEMISTRY TV, as we explore how insulin clearance, or lack of it, contributes to metabolic
troubles. Better Body Chemistry TV is brought to you by Dr Sandy – a scientist turned gremlin
buster, HELPING YOU, battle sugar gremlins, heffa-lumps & other health horribles, through
BETTER BODY CHEMISTRY. Remember, small things can make a big difference to your health.
Maybe this has happened to you, you’ve come round the corner, to find dirty smelly water
oozing out…. THE DRAIN IS BLOCKED. Now, if you can calm down sufficiently to analyse
the situation, the problem is not as a result of too much water, an obstruction in the pipe,
is causing the water to NOT LEAVE. So it starts to accumulate. And………….. you end up
with a plumbing disaster. Could this be what happens in hyperinsulinemia ? Mindful of the
connection between too much insulin and fatness, a team of German researchers set about studying
insulin clearance rates. But rather than start with fat people, they started with skinny
guys. This is a little unconventional. They chose this approach, because they wanted to
see what happens, before EVERYTHING gets broken – which is often the state of play, when you’ve
turned into an overweight couch potato. 10 healthy, physical active, non-smoking, medication
free twenty something males, with good pedigrees (none of their relatives had metabolic syndrome),
signed up to become……….. BLOBS. They took to eating 300 – 500 extra kilocalories
a day. And they were considered SUCCESSFUL, when they had managed to bump up their BMI
by 2 points and keep it there for at least 4 weeks. This saw them go from a BMI of 21.8
 0.7 to 23.8  0.8 . To be considered overweight, you need to have a BMI of more
than 25, to be obese, the figure jumps to, more than 30. So these guys were not exactly
BLOBS, even at their heaviest. But, their biochemistry had changed. And the extra calories
changed their post meal curves – A LITTLE. They were still all 100 % normal, but the
spike in insulin was marginally higher, while glucose levels remained pretty much the same,
every time they tested. And they were tested on three different occasions, in three different
ways. The first test was to see how they handled a standard meal (marmalade on toast. The second
test was 75 g of glucose dissolved in 300 ml of water (this is a oral glucose tolerance
test). And the third test was a glucose infusion. The bump in insulin, implied a decrease in
insulin sensitivity i.e. they had become a little insulin resistant. Using the results
from the glucose infusion, the team deduced….the extra insulin floating through the system,
was as a result of the insulin that was being produced, hanging around for longer. It wasn’t
being removed timeously. Removing insulin ? Yes. Your body is constantly making and
breaking stuff. Cells that respond to insulin, put him in their trash can, once he’s delivered
his message. But, when the pancreas pumps out insulin, thanks to the arrangement of
the blood vessel “wiring”, it first goes to the liver. Now, the liver vets the entry
of all chemicals into the body……… ALL. Even though insulin is “home-made”, it
doesn’t get a clear pass through passport control. Estimates vary, but somewhere between
50 – 75 % of the insulin, doesn’t MAKE IT. It gets destroyed, by insulin degrading
enzymes. Now in our the newbie “chubbies” – this process of removing the insulin,
was less efficient. This research estimated, it was down by around 50 % less efficient.
Resulting in more insulin entering the circulation. And more insulin in circulation, means more
insulin is available to get up to mischief. The liver must be “ loafing”, allowing
the “drain” to be blocked. Time to blame the liver ? Maybe. Maybe not. As with all
things biological, it’s probably a lot more complicated. It turns out, insulin clearance
in the liver, depends on how much zinc is packaged in the insulin granules. Which depends
on the activity of a zinc transporter, which depends on your genes and how many yellow
vegetables you’re eating. The plot thickens…………….. to “win” the battle, you must rein in
insulin. Decreasing insulin production can help, but it’s not enough if the drain is
blocked. One way to unblock the drain, is by eating your yellows. For more tips and
strategies that will help create BETTER BODY CHEMISTRY and better health. Visit our website
WWW BETTER BODY CHEMISTRY dot COM, browse our library or enrol in one of our courses
or programmes. The advice is simple to follow and based on real science, not hype. Know
someone who is “short” of insulin ? Share this video with them – so they understand
insulin shortages are relative. And if you enjoyed the video, be sure to subscribe to
our channel, so you catch future episodes of BETTER BODY CHEMISTRY TV. Thank you so
much for watching and I will see you next time. Remember small things can make a big
difference to your health.