Lipotoxicity: How Saturated Fat Raises Blood Sugar

Lipotoxicity: How Saturated Fat Raises Blood Sugar

August 19, 2019 54 By Jose Scott


the association between fat and insulin resistance is now widely accepted so-called ectopic fat accumulation the accumulation of fat in places is not supposed to be like within our muscle cells but all fats don’t affect muscles the same the type of fat saturated versus unsaturated is critical saturated fats like palmitate found mostly meat dairy eggs cause insulin resistance but Oleg ate the mostly nuts olives avocados may actually improve insulin sensitivity what makes saturated fat bad saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction increase oxidative stress for gradalls inflammation causing a vicious cycle of events in which saturated fat induce free radical causes dysfunction little power plants within our muscle cells which cause an increase in free radical production and impairment of insulin signaling fat cells filled with saturated fat activate an inflammatory response to a far greater extent this increased inflammation along with eating more saturated fat has been demonstrated to cause insulin resistance to free radical and ceramide production saturated fat has also been shown to have a direct effect on skeletal muscle insulin resistance accumulation of saturated fat increases the amount of diacylglycerol on our muscles which has been demonstrated of a potent effect on muscle insulin resistance and doesn’t matter if the muscle in our blood is excuse me in the fat in our blood comes from our own fat or from their fat you can take muscle biopsies from people and correlate the saturated fat build-up in their muscles with insulin resistance while monounsaturated fats are more likely to be detoxified or safely stored away saturated fats create these toxic breakdown products like ceramide that cause lipo toxicity lipo meaning fat as in liposuction and toxicity this fat toxicity in our muscles is a well-known concept in the explanation of the trigger for insulin resistance I’ve talked about the role saturated trans fats contributing a progression of other diseases like autoimmune diseases cancer heart disease they can also cause insulin resistance the underlying cause of pre-diabetes and type 2 diabetes in the human diet saturated fats are derived from animal sources while trans fats originate meat milk conditioner partially hydrogenated and refined vegetable oils that’s why experimentally shifting people from animal fats to plant fats can improve insulin sensitivity in some insulin sensitivity was impaired on the diet with act added butter fat but not on the diet with added olive fat we know prolonged exposure of our muscles to high levels of fat leads to severe insulin resistance with saturated fats demonstrated to be the worst but they don’t just lead to inhibition of insulin signaling the activation of inflammatory pathways and the increase in free radicals they cause an alteration in gene expression leading to a suppression of key mitochondrial enzymes like quarantine palmitoyl transferase which finally solves the mystery of why those eating vegetarian have 60% higher expression of that fat-burning enzyme they’re eating less saturated fat so do those eating plant-based diets have less fat clogging their muscles and less insulin resistance too well there hasn’t been any data available regarding the insulin sensitivity or inside muscle cell fat of those eating vegan or vegetarian until now researchers at the Imperial College of London compared the insulin resistance and muscle fat of vegans versus omnivores now those eating plant-based diets have the unfair advantage of being so much slimmer so they found omnivores who were as skinny as vegans to see if plant-based diets had a direct effect as opposed to indirectly pulling fat out of muscles by helping people lose weight in general they found significantly less fat trapped in the muscle cells of vegans compared to omnivores even at the same body weight they found better insulin sensitivity better blood sugar levels better insulin levels and excitingly significantly improved beta cell function the cells in the pancreas that make the insulin in the first place they conclude that eating plant-based is not only expected to be cardioprotective helping prevent our number one killer heart disease but that it may be beta protective beta cell protective as well helping also to prevent our seventh leading cause of death diabetes you