Insulin Preparations | Pharmacology | Medi tutorials

Insulin Preparations | Pharmacology | Medi tutorials

January 12, 2020 1 By Jose Scott


Insulin preparation Insulin is a small protein containg two polypeptide
chain connected by disulfide bonds. key points:
*Insulin can be exists as- monomer, dimer, hexamer. *It is stored in the granules of pancreatic
B-cell. *Monomer is the biological active form of
insulin. *Molecular weight of insulin is 5808. Now Insulin Preparation : *Rapid acting insulin. *Short acting insulin. *Intermediate acting insulin. *Pre-mixed insulin. *Long acting insulin. *Rapid acting insulin:
Insulin lispro Insulin Aspart
Insulin Glulisine. *Short acting insulin:
Regular Novolin R Regular Humulin R
Velosulin Regular Exubera. *Intermediate acting insulin:
NPH Humulin N NPH Novolin N. *Pre-mixed insulin:
Novolin 70/30 Humulin 70/30
50/50 NPL 75/25 NPL
70/30 NPA (here NPL=neutral protamine lispro. NPA=neutral protamine aspart.) *Long acting insulin:
Insulin determir Insulin glargine. Pre-mixed insulin is produced by combination
of regular, intermediate, short acting insulin, that’s why it is given to the patients at
1 dose within 24 hours! That’s All….