How ketones may not only be fueling us, but changing our gene expression.

How ketones may not only be fueling us, but changing our gene expression.

October 31, 2019 0 By Jose Scott


The presence of ketones in our body is not just good for helping
us run on fats for fuel or helping improve our cognitive function, or helping us lose weight. No, believe it or not, these ketones are now showing evidence of being
able to change our genes and change how our body actually
sends and receives signals. They essentially have a mind of their own. This is some pretty darn cool science that’s starting to come out. Hey, I’m Thomas DeLauer with Keto-Mojo, and today we’re breaking down how ketones are not just fueling us, but changing us. You see, beta-hydroxybutyrate
is known as a lygen. Now, lygens affect receptors
in our bodies on cells. For example, beta-hydroxybutyrate triggers a specific receptor on a cell
known as the HCAR2 receptor. Now, what this means is that the body has the ability to recognize a
ketone as something different. I’m going to make some sense of this. It sounds a little complex at first, but I promise it’s actually quite simple. What this essentially
means, is when a cell sees beta-hydroxybutyrate,
the main ketone body, it has its own ability,
and its own receptor to actually recognize that ketone, and know when we have too
much in the way of ketones. So what that means is, if
we have a bunch of ketones coming in the body
because we’re in ketosis, the cell has the ability to say, “oh wait, I’ve seen enough ketones, I can slow down production.” Meaning it creates its own feedback loop, very similar to how hormones would. Why is this so fascinating? Well, it’s the only
fuel source in the body that can do this. That doesn’t happen with glucose. For example, if we
overeat a bunch of carbs, our cells don’t just say, uh you can stop the production of glucose. No, glucose is going to stay there. But our bodies do have the ability to say hey, stop the production
of ketones for a minute. The reason this is so fascinating is because it means that ketones
essentially have a brain. And our cells essentially
have a brain for ketones. So it’s a really interesting process. Another really clear example of this is what’s called the FFAR3 gene. Okay, this FFAR3 gene is
very, very tightly regulated, and it’s very commonly found in what’s called the
sympathetic nervous system. So like when we get our
“fight or flight” instance on, when we get triggered for some reason and our heart rate goes up and we go into what’s called the
sympathetic nervous system, we activate this gene. Well what’s interesting,
is science is now proving that the ketogenic diet and the presence of beta-hydroxybutyrate
actually affect this FFAR gene. So they affect it to the point
where our heart rate drops, and we don’t go into that sympathetic nervous system as much. So have you ever noticed when
you’re on a ketogenic diet, your heart rate’s a little
bit lower, and you can do cardio and not get your
heart rate quite as high. Well it’s simply because of this. Because actually affecting
us at the genetic level. This is very profound stuff. Now let’s take it one step further. You see, beta-hydroxybutyrate,
just like the name implies, looks a lot like something
known as butyrate. Butyrate is a short chain fatty acid that’s naturally produced in our body whenever we digest fiber
or specific good foods. And butyrate does some
really amazing things. It affects what’s called
gene transcription, and actually can make it
so our genetics sort of mitigate some of the
inflammation within our bodies. It’s a very good thing when we
don’t want a lot of inflammation. So when our own genetic
system is turned on to mitigate inflammation,
we’re in a really good state. Well, that’s from butyrate. But beta-hydroxybutyrate, the ketone, looks so much like butyrate
that it does the same thing. So that means, by having a
presence of ketones in our body at all times from being
in a state of ketosis, we can actually have what’s called this deacetylase inhibiting effect. Now that’s complex, but
essentially what it means is, we constantly are turning
on our genetic potential to modulate inflammation. Again, sugar’s not going to do that. Ketones have a mind of their own. Now everything that I’m describing here is the perfect reason why you need to be testing your ketones. It’s not a simple equation. It’s not as simple as eat
more fats, ketones go higher. It doesn’t work like that, especially since our bodies
have that feedback loop where we can have a bunch
of ketones in the body, and eat a bunch of fats, but our cells aren’t always
going to accept them. And it might send a signal to
slow down production of them. So the point is, we
need to test frequently so that we know our body’s cycles, and we know our bio-individuality. Because ketones, like I’ve
said many times before in this video, have a mind of their own. And they’re revolutionizing
the way that our genetics work, and it’s revolutionizing
our own genetic potential. Make sure you’re leaving all the guesswork out of the equation, and leave
the measuring to the meter. And make sure you’re
using that gold standard when it comes down to
ketone blood testing, and we’re talking about
the Keto-Mojo meter. I’ll see you in the next video.