Growth hormone defect protects against cancer, diabetes, and cognitive decline

Growth hormone defect protects against cancer, diabetes, and cognitive decline

October 30, 2019 3 By Jose Scott


[Rhonda]: For people that are listening and
kind of wondering, we’re talking about one of the major dietary regulators of the IGF-1
pathway which maybe you can mention a little bit about the role of IGF-1 in the aging process. [Valter]: Yeah. So, proteins, and particularly certain amino
acids, methionine, cysteine, etc., they regulate IGF-1 levels, and IGF-1 in simple organisms,
at least the orthologs of IGF-1, as well as in mammals seem to have an important role
in aging. It is not clear how much is IGF-1 versus insulin
versus growth hormone receptor-dependent signaling, which is independent of IGF-1 and insulin,
but most likely it is the growth hormone receptor. Growth hormone and growth hormone receptor,
they are the sort of master controllers, and IGF-1 seems to be one of the axis that regulates
or accelerates aging in multiple cell types.