Growth hormone defect protects against cancer, diabetes, and cognitive decline | Valter Longo

Growth hormone defect protects against cancer, diabetes, and cognitive decline | Valter Longo

November 21, 2019 4 By Jose Scott


[Rhonda]: But for people that are listening
and kind of wondering, we’re talking about one of the major dietary regulators of the
IGF-1 pathway which maybe you can mention a little bit about the role of IGF-1 in the
aging process. [Valter]: Yeah. So, proteins, and particularly certain amino
acids, methionine, cysteine, etc., they regulate IGF-1 levels, and IGF-1 in simple organisms,
at least the orthologs of IGF-1, as well as in mammals seem to have an important role
in aging. It is not clear how much is IGF-1 versus insulin
versus growth hormone receptor-dependent signaling, which is independent of IGF-1 and insulin,
but most likely it is the growth hormone receptor. Growth hormone and growth hormone receptor,
they are the sort of master controllers, and IGF-1 seems to be one of the axis that regulates
or accelerates aging in multiple cell types. [Rhonda]: And from humans there are some,
there’s some evidence with polymorphisms and various like growth hormone…? [Valter]: Yeah, that’s actually our work with
not polymorphism but mutations in the growth hormone receptor, something called E180 mutation. And the people…Well, we knew from mice,
from the work of John Kopchick and Andrzej Bartke, that mice that have either a growth
hormone receptor, or growth hormone deficiency, live longer, about 40% longer, they also live
much healthier. That’s probably, you know, I think one of
the most important observations made in the aging field, that you could live 40% longer,
and yet about half of the mice get to the end of life without any obvious pathological
lesions, so they don’t develop diseases. And that the control of disease is less than
10%. So, and these… [Rhonda]: It’s pretty significant. [Valter]: I’m pointing these out…Well, it’s
a huge effect right there. I’m pointing these out because obviously people
think that if we extend the lifespan of, human lifespan, then it’s going to come with a lot
of more problems. And instead, in the mice, but also in our
work in humans, where we’ve been following these people with growth hormone receptor
deficiency down in Ecuador, and they’re called, there’s a syndrome there, a syndrome called
Laron’s syndrome. So they’re very much the equivalent to the
mice, and they don’t have a very long lifespan, they may live a few years more than their
relatives, they don’t have homozygous growth hormone receptor deficiency, but they’re protected
from cancer, they’re protected from diabetes, and a recent paper showed that they seem to
be protected from age-dependent cognitive decline, and all of these are matched by the
mouse work.