Dr. Allison Goldfine at the Joslin International Symposium on Diabetes

Dr. Allison Goldfine at the Joslin International Symposium on Diabetes

November 3, 2019 0 By Jose Scott


during the 2013 joslin international
symposium on diabetes scientists gathered in Boston to talk
about their research in honor of Dr. C Ronald Kahn a man
who has made tremendous contributions to the fight against diabetes we caught up with a few Joslin researchers who spoke at the event so we know that the insulin receptor
and the insulin signaling proteins are present on the beta cells the cells that make insulin themselves and the question is what would happen if you made it the beta cells resistant to insulin by
knocking out the insulin receptor and this was done by Rohit Kulkarni and Ron
Khan and they showed that the animals lost the ability to
secrete insulin normally in response to glucose stimulus which is very much like what we see in type 2
diabetes so we ask the question whether or not this was physiologically relevant in humans and we took people and we exposed them to higher levels of insulin while maintaining their blood sugars normal and then increased the blood sugars to
see whether or not that would change how much insulin they could secrete in
response to glucose if they had been previously exposed to
higher insulin concentrations indeed we did show that pre-exposure to
insulin would improve beta-cell function and increase the
amount insulin you could secrete in response to the glucose stimulus so the next
question is whether or not this was decreased in people who were insulin resistant or had type 2
diabetes and we’ve repeated these experiments in
patients who had either impaired glucose tolerance or type 2 diabetes and showed that the of ability insulin to augment beta-cell function was
diminished in people who were insulin resistant or had type 2 diabetes suggesting that insulin responsiveness within the
beta-cell is important physiologically in people and could potentially couple the defects that we see between peripheral
insulin resistance and beta-cell function that underlie the pathogenesis of type 2
diabetes in people I would very much like to say words in
honor of Ron Kahn he has been a mentor to many of us and what I would like to say is he has looked at the world from a different
perspective thinking outside the box and he has given us the courage to jump and the wings to fly thank you Ron