CV Inflammation Test: What is it? How to get it? Does it impact the glycocalyx?
Inflammation. Time magazine knew about
this 15 years ago. This is a cover article from 2004, “The Secret Killer: The
Surprising Link Between inflammation and Heart Attacks, Cancer, Alzheimer’s, and
Other Diseases, and What You Can Do to Fight It.” How about the medical establishment? Well, the standards committees know that it exists. They’ve bantered back and
forth on whether to look at C-reactive protein, and C-reactive protein doesn’t
have a great… it’s got too many false positives, and they know it. So they’re
still trying to work through it. I don’t think I’d wait. I think I’d go ahead and
get that test. In fact, I did I get that test on a regular basis for myself as
well as my loved ones as well as my patients. Well, what is inflammation and
what why does it matter? Well, that’s actually burning up that… in that
glycocalyx? What is the glycocalyx? It’s a fuzzy lining to the intima, the slick
lining of the artery walls. Now why is that important?
That glycocalyx protects us protects the artery wall from what’s inside the blood
flow, for example, LDL. In fact, plaque is nothing but LDL. What we used to call bad
cholesterol (low-density lipoprotein), plaque is nothing but LDL that has gone
through the glycocalyx and lodged in the artery wall. Now, how does that happen?
Well, as you see up here, here’s the the artery – the intima, the media. That’s the
summary. It gets a lot more complicated in terms of layers but you don’t need to
remember all that. Look at this next image. These are a couple of images of
the glycocalyx. This is an actual picture of a glycocalyx, and you see it’s lining
the artery wall. This is a diagram of it in the purple and pink here. This
picture below is a full, healthy glycocalyx. And as you see over here, part
C here, this small one is a damaged plaque. Okay, looks as you can see it’s
much much thinner. Let’s take a different look and a maybe clearer look. This is a
nice, healthy glycocalyx, part A here. And look at this one. This is an injured
glycocalyx, part B here. Now what kind of it?
Like somebody came home, who came through an uncut field with a lawnmower. Now
you can… after seeing that visual, you can begin to understand a lot better why
inflammation is actually just the major issue that causes heart attacks and
strokes. Because it’s the major issue that results in plaque buildup.
We’ve been going down the wrong road focusing on the cholesterol or how
high our LDL is. As you can see, it doesn’t matter how high your LDL is. If
you’ve got a nice healthy glycocalyx, and and if you’ve got a damaged one, it’s
gonna get through the damaged one even at low levels. And it’s not gonna get
through the nice healthy glycocalyx. Now what causes this kind of damage to the
glycocalyx? By far, the most common is elevated blood sugar from insulin
resistance, prediabetes, metabolic syndrome. Another cause is high insulin
insulin itself will damage that glycocalyx. Cigarette smoke is lethal to
the glycocalyx. Other inflammatory diseases caused problems as well, and
other chemicals. Now let’s just take a quick look. Yeah, we’ve talked many times
about the webinar series and how we’ve mislabeled it. The webinar series is
actually set up to give you access to the inflammation panel. And this is a
copy of my inflammation panel from 2015. I used this image because this is the
only time I’ve ever seen Quest labs put the whole inflammation panel all
together you know in one section. Myeloperoxidase nd PLAC2, these two
are enzymes that are actually released by immune cells that are trying to
attack that plaque in the artery wall. CRP (C-reactive protein) is a protein that the docs, when they do look for cardiovascular inflammation, actually
will often use that but they’ll use it alone. Why don’t we use it alone? Well
it’s way too high false-positive rate. If we did a 100 flu shots today, 60 of those
patients would have a positive C-reactive protein two days from now. So that’s way too many false positives. Microalbumin
creatinine ratio is the most important of the inflammatory tests. What that
tests for is damage to that glycocalyx and intima layer. It’s looking to see if
protein is escaping through the filters of the kidney. Because the filter membrane of the kidney is the intima. That’s what it is.
And if protein albumin can filter through that kidney into the urine,
then plaque/LDL can filter through that glycocalyx, that intima, to form plaque.
Let me just repeat that because it’s a little bit complicated. If albumin can
filter through the intima and glycocalyx of the kidneys into the urine, then LDL
can filter through the glycocalyx and intima in the rest of the body to form
plaque. Now here’s a patient that had… here’s another version of it. As I
said, they hardly ever put them all together. I had to piece these together.
And this patient had good C-reactive protein, good myeloperoxidase, and PLAC2. His microalbumin creatinine was a little bit elevated. This was a male, and
in males, we wanted 7 or below. This was 10 now. Don’t follow the lab
normals as listed here. At 30, the 30 lab normal are lab limit range
of 30 is for kidney disease. It’s not for cardiovascular risk. But as you can
see here, this patient is actually improving dramatically. He had much worse
values back in 2017 and 2016, so he’s been doing some good work.
Do you know your numbers? If not, you should check them out. Check out the
webinar series. Thank you for your interest. So I’m very excited to announce
we now have a membership page. Now what is that? That’s the one place where you
can go and access all of our digital products. It starts
off with a few free things, like a lot of infographics which help you understand
the basics of insulin resistance, cardiovascular inflammation, and other
key concepts on how to prevent heart attack and stroke. The next free item is
the intro and first chapter of the book that we’re writing on plaque and the
standards of medicine just aren’t doing very well right now in terms of the
number one killer and disabler – plaque. We don’t do a good job of measuring it, we
don’t do a good job of monitoring it, and there are better ways. So that’s what
this book is all about. Again, go in, and get a free a look at the intro and
the first chapter. And if you’ve purchased the cardiovascular
inflammation and IR courses, thank you so much for doing that.
You purchased those at a time before we had them totally cleaned up. And we’ve
cleaned them up now, and they’re available for you right there on the
membership page. Hit the link below, register and go in, and take a look. Look
forward to seeing you there. Thank you.