A Newfound Link Between Diabetes and Pancreatic Cancer

A Newfound Link Between Diabetes and Pancreatic Cancer

November 3, 2019 7 By Jose Scott


This is another article about the link
between insulin resistance and pancreatic cancer. When I did the video
on pancreatic cancer or a few weeks ago, we got a lot of responses. We’ve got
several viewers and subscribers who either have pancreatic cancer or have
pancreatic masses. One of them actually provided me this article and it’s good.
It’s a good one. This is basically just a lay article in
Cancer Therapy Advisor. It’s reporting out on an article that was published in
Cell magazine, a very well-respected genetics and biology journal. The title
is self-explanatory: Disrupted Glucose Metabolism Led to High Levels of DNA
Damage in Pancreatic Tissue. So we’re talking about pancreatic ductal
adenocarcinoma (PDAC). It’s the most common type of pancreatic
cancer, contributes to about 95% of cases. It’s the most aggressive and
lethal cancer out of the top 60 organ cancers. One of the major reasons this is
so difficult to find pancreatic cancer in its early stages more than 90% of the
PDACs contain mutations and genetic problems that are thought to be involved
in initiating the malignant transformation of these cancers. It’s a
mutated KRAS pathway, leading to deregulation of glucose glutamine and
nucleic acid metabolism, allowing for quick and uncontrolled proliferation of
PDAC cells. And that’s exactly what cancer is – uncontrolled replication or
proliferation of these cells. They used a well-known, well-established method of
looking at DNA damage. It’s called gamma-H2AX. It’s a type of
staining which shows double strand breaks in DNA. They compared that
to non-malignant samples from the people with and without a history of
diabetes but also had pancreatic cancer. Patients with diabetes had significantly
more DNA damage than those without. And this effect appeared to be a pancreas-
specific. Control intestines examples showed no difference in DNA damage
between individuals with and without diabetes. So finding that connection, then
they went back to lab rats, and they said they fed lab rats a group of lab rats
high sugar, high fat diet for 20 weeks and then started doing tests
DNA damage to the lab rats’ pancreas. What they found was sure enough
the rats with impaired glucose metaboilism also had increased breakage in the
double strands of the DNA. So yet again, another link between insulin resistance
and devastating disease. Thank you very much for your interest. I’ve had so many
patients come to me because they quote their diet here “Why don’t you take this
statin and let’s see what happens… let’s see if a heart attack or stroke
happens.” No, prevention is a science. We know what’s going to happen. We know what
to look for, we know how to prevent it. Come see us in Louisville on November
8th and 9th. Get your CIMT artery scan, all your labs. See me and spend two days
learning usually what your doctor doesn’t know yet about the science of
prevention. Look forward to seeing you there. Thanks.